Business ethics educators strive to produce graduates who not only grasp the principles of ethical decision-making, but who can apply that business ethics education when faced with real-world challenges. However, this has proven especially difficult, as good intentions do not always translate into ethical awareness and action. Complementing a behavioral ethics approach with insights from social psychology, we developed an interventional class module with both online and in-class elements aimed at increasing students’ awareness of their own susceptibility to unconscious biases (...) and, consequently, unethical behaviors. We deployed this intervention within a problem-based learning course, in which students completed real-world projects for actual business clients. Our results suggest that although students appeared universally aware of the importance of ethical issues in business and generally espoused intentions to act ethically, those who received the intervention were significantly more likely to recognize their own susceptibility to perpetuating unethical business behavior and to identify ethical issues specific to their real-world projects. These results have important implications for behavioral ethics pedagogy and provide a de-biasing interventional approach for bridging classroom knowledge with real-world skills. (shrink)

Understanding the clinical significance of variants associated with hereditary cancer risk requires access to a pooled data resource or network of resources—a “cancer gene variant commons”—incorporating representative, well-characterized genetic data, metadata, and, for some purposes, pathways to case-level data. Several initiatives have invested significant resources into collecting and sharing cancer gene variant data, but further progress hinges on identifying and addressing unresolved policy issues. This commentary provides insights from a modified policy Delphi process involving experts from a range of stakeholder (...) groups involved in the data-sharing ecosystem. In particular, we describe policy issues and options generated by Delphi participants in five domains critical to the development of an effective cancer gene variant commons: incentives, financial sustainability, privacy and security, equity, and data quality. Our intention is to stimulate wider discussion and lay a foundation for further work evaluating policy options more in-depth and mapping them to those who have the power to bring about change. Addressing issues in these five domains will contribute to a cancer gene variant commons that supports better care for at-risk and affected patients, empowers patient communities, and advances research on hereditary cancers. (shrink)

This latest volume of BACAP Proceedings contains some innovative research by international scholars on Plato, Aristotle, and Sophocles. It covers such themes as Plato on the philosopher ruler, and Aristotle on essence and necessity in science. This publication has also been published in paperback, please click here for details.

We report the identification of a recurrent, 520-kb 16p12.1 microdeletion associated with childhood developmental delay. The microdeletion was detected in 20 of 11,873 cases compared with 2 of 8,540 controls and replicated in a second series of 22 of 9,254 cases compared with 6 of 6,299 controls. Most deletions were inherited, with carrier parents likely to manifest neuropsychiatric phenotypes compared to non-carrier parents. Probands were more likely to carry an additional large copy-number variant when compared to matched controls. The clinical (...) features of individuals with two mutations were distinct from and/or more severe than those of individuals carrying only the co-occurring mutation. Our data support a two-hit model in which the 16p12.1 microdeletion both predisposes to neuropsychiatric phenotypes as a single event and exacerbates neurodevelopmental phenotypes in association with other large deletions or duplications. Analysis of other microdeletions with variable expressivity indicates that this two-hit model might be more generally applicable to neuropsychiatric disease. © 2010 Nature America, Inc. All rights reserved. (shrink)

(Anna Maria Taigi 1769 - 1837)St. Alphonsus writes: "a single bad book will be sufficient to cause the destruction of a monastery." Pope Pius XII wrote in 1947 at the beatification of Blessed Maria Goretti: "There rises to Our lips the cry of the Saviour: 'Woe to the world because of scandals!' (Matthew 18:7). Woe to those who consciously and deliberately spread corruption-in novels, newspapers, magazines, theaters, films, in a world of immodesty!" We at St. Pius X Press are calling (...) for a crusade of good books. We want to restore 1,000 old Catholic books to the market. We ask for your assistance and prayers. This book is a photographic reprint of the original. The original has been inspected and many imperfections in the existing copy have been corrected. At Saint Pius X Press our goal is to remain faithful to the original in both photographic reproductions and in textual reproductions that are reprinted. Photographic reproductions are given a page by page inspection, whereas textual reproductions are proofread to correct any errors in reproduction. (shrink)

This book moves beyond traditional readings of Alexis de Tocqueville and his relevance to contemporary democracy by emphasizing the relationship of his life and work to modern feminist thought. Within the resurgence of political interest in Tocqueville during the past two decades, especially in the United States, there has been significant scholarly attention to the place of gender, race, and colonialism in his work. This is the first edited volume to gather together a range of this creative scholarship. It reveals (...) a tidal shift in the reception history of Tocqueville as a result of his serious engagement by feminist, gender, postcolonial, and critical race theorists. The volume highlights the expressly normative nature of Tocqueville’s project, thus providing an overdue counterweight to the conventional understanding of Tocquevillean America as an actual place in time and history. By reading Tocqueville alongside the writings of early women’s rights activists, ethnologists, critical race theorists, contemporary feminists, neoconservatives, and his French contemporaries, among others, this book produces a variety of Tocquevilles that unsettles the hegemonic view of his work. Seen as a philosophical source and a political authority for modern democracies since the publication of the twin volumes of _Democracy in America _, Tocqueville emerges from this collection as a vital interlocutor for democratic theorists confronting the power relations generated by intersections of gender, sexual, racial, class, ethnic, national, and colonial identities. In addition to the editors, the contributors are Jocelyn Boryczka, Richard Boyd, Christine Carey, Barbara Cruikshank, Laura Janara, Matthew Holbreich, Kathleen S. Sullivan, Alvin B. Tillery Jr., Lisa Pace Vetter, Dana Villa, Cheryl B. Welch, and Delba Winthrop. (shrink)

Jill de Villiers has argued that children's mastery of sentential complements plays a crucial role in enabling them to succeed at false-belief tasks. Josef Perner has disputed that and has argued that mastery of false-belief tasks requires an understanding of the multiplicity of perspectives. This paper attempts to resolve the debate by explicating attributions of desires and beliefs as extensions of the linguistic practices of making commands and assertions, respectively. In terms of these linguistic practices one can explain why (...) desire-talk will precede belief-talk and why even older children will have difficulty attributing incompatible desires. (shrink)

Jill de Villiers has argued that children's mastery of sentential complements plays a crucial role in enabling them to succeed at false-belief tasks. Josef Perner has disputed that and has argued that mastery of false-belief tasks requires an understanding of the multiplicity of perspectives. This paper attempts to resolve the debate by explicating attributions of desires and beliefs as extensions of the linguistic practices of making commands and assertions, respectively. In terms of these linguistic practices one can explain why (...) desire-talk will precede belief-talk and why even older children will have difficulty attributing incompatible desires. (shrink)

In this article, I shall contend that Rawlsian public reason liberalism (PRL) is in tension with non-anthropocentric environmentalism. I will argue that many reasonable citizens reject non-anthropocentric values, and PRL cannot allow them to be used as the justification for ecological policies. I will analyse attempts to argue that PRL can incorporate non-anthropocentric ideas. I shall consider the view, deployed by theorists such as Derek Bell and Mark A. Michael, that PRL can make a distinction between constitutional essentials and non-essentials, (...) and therefore ecocentric values can be employed when only non-essentials are at stake. I will also consider Simon Hailwood’s argument that PRL can incorporate concern for nature based on its ‘otherness’. I shall conclude that both positions fail to rebut the claim that PRL excludes non-anthropocentric viewpoints. I will consider the question of whether PRL’s exclusion of non-anthropocentric ethics is a problem, and I shall show that appealing to purely anthropocentric arguments leads to a variety of unpalatable conclusions. I will suggest that comprehensive liberalism can include non-anthropocentric concerns, and hence is superior from an environmental perspective. (shrink)

Lucas Matthews and I substantially revised my SEP entry on Heritability. This version includes discussion of the missing heritability problem and other issues that arise from the use of Genome Wide Association Studies by Behavioral Geneticists.

This chapter contains section titled: Further Reading Notes.

This chapter contains section titled: Standard Analysis First Alternative Analysis Second Alternative Analysis Third Alternative Analysis of Lying Fourth Alternative Analysis Further Reading.

This chapter contains section titled: Further Reading Notes.

This chapter contains section titled: Argument A Argument B Argument C Further Reading Notes.

This chapter contains section titled: Further Reading Notes.

In this introduction we set out some salient themes that will help structure understanding of a complex set of intersecting issues discussed in this special issue on the work of Marc Lewis: conceptual foundations of the disease model, tolerating the disease model given socio-political environments, and A third wave: refining conceptualization of addiction in the light of Lewis’s model.

In lieu of an abstract, here is a brief excerpt of the content:Reaching the Age of Majority:The Life Trajectory of the CIHR Institute of AgingYves Joanette, Anne Martin-Matthews, Réjean Hebert, and Joanne GoldbergThe Canadian Institutes of Health Research (CIHR) was created in 2001 under the Canadian Institutes of Health Research Act S.C. 2000, c. 6 (Government of Canada, 2000). The creation of CIHR was in follow-up to the Canadian Medical Research Council (MRC) as well as to the National Health (...) Research and Development Program of Health Canada that, up until that point in time, had supported the breadth of health research in Canada. Two important characteristics of CIHR were crucial for the development of research on aging. The first was that CIHR, unlike MRC, was entrusted with the challenge of supporting the whole spectrum of health research, from the basic biomedical perspective to clinical research, research on health services and policies as well as social aspects of health research, not to mention research on ethics and other perspectives (including the science of research). The second characteristic of the nascent CIHR that impacted the community of research on aging was the decision that a small part of the overall CIHR budget would be used to address priority-driven questions or topics (strategic competitions), while the majority of the budget would be invested in grants and awards programs that would be investigator-initiated, as in the time of the MRC (open competition). Since its inception, CIHR has included 13 institutes that are central to the priority-driven actions. Institutes not only play an important convener role within their communities and among their stakeholders, but they are also expected to listen to the needs, gaps and opportunities in their area and to introduce initiatives---most of the time involving more than one Institute---in order to tackle these needs and gaps and to seize upon the opportunities.The Institute of Aging was introduced at the same time as the other 12 Institutes and it is clear that many challenges were awaiting the new Institute since, at that time, research on aging was still in its early years. This article is about the trajectory of the CIHR Institute of Aging in its first 18 years of existence. Having now reached an age that is either the age of majority or quite close to it, it is important to be able to provide a reflection on the evolution of the priorities over this period, while also taking a peek at some of the priorities that will surely come in the near future.The Early Years (2001-2004)The founding Scientific Director of the Institute of Aging was Dr. Réjean Hébert. A well-known and prolific [End Page 1] geriatrician and researcher, Dr. Hébert was the perfect person to launch the Institute. One of his first actions was, in fact, to harmonize the French and English names of the Institute. In French, the name of the Institute focused on Aging (Institut du vieillissement) while, in English, the name of the Institute focused on Healthy Aging. The CIHR Institute of Healthy Aging thus became the CIHR Institute of Aging in all versions of its documentation. But above and beyond this important name change, the real work of Dr. Hebert, accompanied by the first Institute Advisory Board1, chaired by Prof. Dorothy Pringle, was to identify the gaps, the needs and the opportunities. After a rigorous process came the first Strategic Plan of the CIHR Institute of Aging, which was clearly influenced by Dr. Réjean Hébert's vision of the aging population as an opportunity, instead of a catastrophe, for our society that comes, of course, with its own challenges. Dr. Hébert left CIHR during his first mandate as he was called upon to become the Dean of his Faculty, and then went on to become the first CIHR Scientific Director to sit as a Minister of Health and Social Services in the Québec Government. The main outcomes of Dr. Hebert's years (2001-2004) can be summarized as follows2.• Organizing many workshops and meetings to ensure that the Institute of Aging would become the premier national convener for research on aging, bridging between disciplines... (shrink)

A strong case has been made for the role and value of mechanistic explanation in neuroscience and molecular biology. A similar demonstration in other domains of scientific investigation, however, remains an important challenge of scope for the new mechanists. This article helps answer that challenge by demonstrating one valuable role mechanisms play in phylogenetics. Using the transition/transversion rate parameter as a case example, this article argues that models embedded with mechanisms produce stronger phylogenetic tree hypotheses, as measured by maximum likelihood (...) logL values. Two important implications for the new mechanistic account of explanation are considered. (shrink)

This essay constructs a picture of the meaning of life based on De Anima 2. 2-4. It shows that there are organisms that preserve their form through the exercise of identifiable functions. For an individual to be a short, living thing is for it to be one of these naturally species-preserving organisms. For an individual living thing to be actually living is for it to be able to perform one of the psychic or living functions appropriate to its species.

The deflationary aim of this book, which occupies Part I, is to show that a widely held view has little to be said for it. The constructive aim, pursued in Part II, is to make plausible a measure-theoretic account of propositional attitudes. The discussion is throughout instructive, illuminating and sensitive to the many intricacies surrounding attitude ascriptions and how they can carry information about a subject's psychology. There is close engagement with cognitive science. The book should be read by anyone (...) seriously engaged with issues about propositional attitudes.According to the widely held view, which Matthews calls the Received View, the attitude of Φing that p is a matter of standing in a computational/functional relation to an explicit Representation that expresses the proposition that p, and thinking is ‘an inferential computational process defined over one or more of these Representations that eventuates in the production of either another Representation or a behavior’. The representations are understood to be sentences in a language of thought and thus to have a compositional syntax and semantics. The theory that Matthews aims to make plausible has it that ascriptions of propositional attitudes in the form ‘X Φs that p’, ascribe a state to a person by relating that person to an abstract object that is the representative of the state in roughly the way that numbers on a scale are the measure-theoretic representations of certain physical magnitudes. We are to think of the role of ‘Jones believes that interest rates will fall’ by analogy with that of ‘Jones weighs 150lbs’. The latter depends on there being arithmetical relations defined over numbers that enable its particular assignment of a number to Jones's weight to represent physical properties that Jones has in virtue …. (shrink)

Classicists and connectionists alike claim to be able to explain systematicity. The proposed classicist explanation, I argue, is little more than a promissory note, one that classicists have no idea how to redeem. Smolensky's (1995) proposed connectionist explanation fares little better: it is not vulnerable to recent classicist objections, but it nonetheless fails, particularly if one requires, as some classicists do, that explanations of systematicity take the form of a‘functional analysis’. Nonetheless, there are, I argue, reasons for cautious optimism about (...) the prospects of a connectionist explanation. (shrink)

In lieu of an abstract, here is a brief excerpt of the content: Against Definition. Eric Matthews. -/- Keywords: definition, mental illness, ideology -/- Varelius rightly says, in the very first sentence of his article, that 'The nature of mental disorder is a controversial issue.' But I do not think he recognizes just how deeply controversial it is. He hopes to be able to find a way of resolving the controversy by his chosen method, based on a consideration of (...) 'the goals that we have in classifying certain persons as mentally disordered.' However, not only does the adoption of that method presuppose that the controversy is resoluble, it is also somewhat circular. For to be able to set out the goals that we have in classifying some people as mentally disordered, we already have to know which persons we so classify, and so what is meant by calling them 'mentally disordered.' There are several appeals to alleged 'intuitions' and one to a 'paradigm case' in Varelius's article; but, if we had such intuitions, they would be all we needed to define the concept of mental disorder, and there would be no need for the further reference to our goals in demarcating this class of human conditions.I want to argue that any alleged 'intuitions' we might have in regard to mental disorder are philosophically useless, and that the controversy about the nature of mental disorder is intrinsically irresoluble. Any claimed intuition can always be met by a rival intuition that is irreconcilable with the first. It is this, indeed, that makes the dispute about mental disorder essentially philosophical, rather than scientific, in character. Philosophical positions have to be based on, and defended by, rational argument, but there necessarily comes a point in any philosophical dispute at which no rational argument can settle the matter one way or the other. Varelius derives his methodology of considering goals of demarcation from some work done using this method on the concept of science. But people have different goals for demarcating 'science' from 'non-science' or 'pseudo-science.' The demarcation is not made, as Varelius suggests, on the basis of such criteria as testability of hypotheses or clarity of concepts; or rather, the application of these criteria themselves is determined by the goals of demarcation. The debate about what is to count as a 'science' is irresoluble in part because what we classify as such has evaluative and practical consequences. To be a 'science,' in our culture, is to be a valued activity, to have a status to be aspired to. This makes arguments about what it is to be scientific what I would like to call 'ideological' in character. Similar considerations apply to the dispute about the nature of mental disorder. Human societies have always distinguished madness from reason, disturbed or disordered behavior, thoughts, and emotions from those that are not disordered. But the purpose of making the distinction, and thus the character of the distinction made, has varied from society to society and from one historical period to another. The historian Roy Porter, in his short work Madness: A Brief History (2002) describes some of the different images of madness which have prevailed at different times in Western culture—as a divine punishment for hubris, as [End Page 53] a source of poetic inspiration, as the inevitable result of moral excess, as diabolical possession, and so on. The modern idea of mental disorder as mental illness is only one possible way of classifying together certain sorts of deviations from normality. Varelius's method of arriving at a definition of mental illness involves 'considering the goals that we have in classifying certain persons as mentally disordered.' But we can ask who are the 'we' in question, and whether 'we' have only one set of goals in classifying people in this way. The history referred to in the preceding paragraph suggests that 'we' means those members of society who do not regard themselves as disordered—the 'normal' people whose behavior can be readily understood by other normal people. Classifying someone as mentally disordered is distinguishing them as 'not one of us,' and this can serve various purposes, for instance, treating them as objects of entertainment in a human zoo, as in Bedlam; or treating them as moral. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Philosophy, Psychiatry, & Psychology 12.3 (2005) 205-207 [Access article in PDF] The Relevance of Phenomenology Eric Matthews Keywords phenomenology, introspective psychology, Merleau-Ponty, melancholia Martin wyllie's paper raises very impor-tant issues about the relevance of phe-nomenology to psychiatry, but the language in which he presents phenomenology unfortunately makes it sound (contrary to his own intentions) too much like empirical introspective psychology. The aim of this commentary is to improve (...) the presentation of phenomenology, drawing particularly on the work of Maurice Merleau-Ponty, to develop Wylie's position and to bring out better the relevance of this approach to our understanding of mental disorder in general and of melancholia/depression in particular.I am essentially in sympathy with Martin Wyllie's account of the phenomenology of what he prefers to call melancholia (and indeed have discussed it with him on numerous occasions). His present paper, as well as containing many valuable insights on that topic, also raises important questions about the relevance of phenomenology to the theory and practice of psychiatry, and it is on those questions that I aim to concentrate in this commentary, in the hope of developing further what Martin has begun. To do this, it is necessary first of all to set out a more thorough account of what is meant, in this context, by phenomenology.Phenomenology is often presented as if it were a kind of empirical introspective psychology, and Martin's choice of language unfortunately sometimes (certainly not always) gives the impression that he shares that understanding of the term. For instance, he says that a phenomenological description of "lived time" tells us " 'what it is like' to experience 'lived time'" (2005, 173); and in other places uses causal terms about the relation between different aspects of lived experience, for example, that are more appropriate to an empirical, scientific, study. This is certainly one accepted use of phenomenology, but it is not what was meant by Husserl and Merleau-Ponty, the two philosophers whom he clearly has most in mind in his paper; and, more important perhaps, it is not the sort of phenomenology likely to shed the most light on the psychiatry of melancholia.In my commentary, therefore, I try to set out as clearly and briefly as I can an alternative and more appropriate account of relevant aspects of phenomenology, in the form with which I am most familiar, that which it takes in the writings of Maurice Merleau-Ponty. For Merleau-Ponty, phenomenology was, just as Husserl, its founder, had described it, "the study of essences" (Merleau-Ponty 2002, vii). That is, it was not an empirical study of the contingent contents of any individual's experience, but an investigation of the universal structures of human experience as such. But at the same time (and here we see a distinctive approach of Merleau-Ponty's own, derived from his reading of Heidegger and the [End Page 205] later Husserl), "phenomenology is also a philosophy which puts essences back into existence" (2002, vii). Human experience is not, for him, that of a "transcendental subject", standing outside the world and simply observing it: human being is, in the phrase he derived from Heidegger, "being-in-the-world". That is, we exist within the world, actively engaging with it, and our experience of it directly "opens on to" the world which we experience.The world is thus "objective" in the sense that it is always already there—we do not create it, we inhabit it, and the world we inhabit necessarily extends beyond our experience of it. But the world we inhabit necessarily has a "subjective" meaning for us, just because we inhabit it and actively engage with it. To take a simple example, we necessarily see some items in the world as food because we experience hunger. These subjective meanings are just as much part of the world as we experience it as the measurable properties of objects in which science is interested. They give sense to the idea that the world is our world, that "subjective" and "objective" are not polar opposites, but are necessarily entangled in our... (shrink)

Classicists and connectionists alike claim to be able to explain systematicity. The proposed classicist explanation, I argue, is little more than a promissory note, one that classicists have no idea how to redeem. Smolensky's (1995) proposed connectionist explanation fares little better: it is not vulnerable to recent classicist objections, but it nonetheless fails, particularly if one requires, as some classicists do, that explanations of systematicity take the form of a‘functional analysis’. Nonetheless, there are, I argue, reasons for cautious optimism about (...) the prospects of a connectionist explanation. (shrink)

We have argued elsewhere that moral responsibility over time depends in part upon the having of psychological connections which facilitate forms of self-control. In this chapter we explore the importance of mental time travel - our ordinary ability to mentally travel to temporal locations outside the present, involving both memory of our personal past and the ability to imagine ourselves in the future - to our agential capacities for planning and control. We suggest that in many individuals with dissociative disorders, (...) forms of amnesia, or other frontal lobe damage, our capacity for mental time travel is impaired, resulting in commensurate losses to agency autonomy, and a forensic condition essential for holding persons responsible: in legal terms, the capacity for mens rea. (shrink)

The organization of the genome into topologically associated domains (TADs) appears to be a fundamental process occurring across a wide range of eukaryote organisms, and it likely plays an important role in providing an architectural foundation for gene regulation. Initial studies emphasized the remarkable parallels between TAD organization in organisms as diverse as Drosophila and mammals. However, whereas CCCTC‐binding factor (CTCF)/cohesin loop extrusion is emerging as a key mechanism for the formation of mammalian topological domains, the genome organization in Drosophila (...) appears to depend primarily on the partitioning of chromatin state domains. Recent work suggesting a fundamental conserved role of chromatin state in building domain architecture is discussed and insights into genome organization from recent studies in Drosophila are considered. (shrink)

The contrast between the reception of Anselms argument in the prior acceptance of univocal or analogical accounts of being. 1 P. A. Daniels argued that the prerequisites for Bonaventureontologicals argument among the first scholastics of the thirteenth century depended upon their allegiance to Augustinian or Aristotelian traditions. 3 Anton Pegis did the same when he insisted that recovery of the Anselmian argument in its original form involved stripping away the Aristotelian framework in terms of which the Proslogion has been read (...) since Thomas. 4. (shrink)

First published in 2000. Routledge is an imprint of Taylor & Francis, an informa company.